Alloy is a US telehealth service for menopause, and its skincare piece is M4 Face Cream Rx, a prescription cream with estriol, the weakest of the three estrogens. Ordering starts with a menopause trained clinician reviewing the medical history, and the bottle that ships holds a three month supply. The company paid for clinical studies in 2023 and again in 2025 to support its claims about collagen, wrinkles and elasticity.
This is for women already comfortable with hormone treatment who want something beyond cosmetics. It does not fit anyone avoiding estrogen, anyone outside the United States, or a shopper who simply wants to drop a jar in a cart, since the consultation is mandatory. Estriol is not FDA approved for treating menopause, a point worth raising with a doctor first.
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